movie showing wound closure rates for control and Rap1 dominant negative embryos
human epithelial cells in the process of closing a wound

Stage 14 Drosophila embryos expressing non-muscle myosin II tagged with GFP (green) and the cell adhesion protein DE-cadherin tagged with tdTomato (magenta) undergoing wound closure. The control embryos (left) repair their wounds within about 45 minutes with significant accumulation of myosin II at the leading edge, while embryos expressing a dominant-negative form of the small GTPase Rap1 (right) take significantly longer to heal and are defective in myosin accumulation.

Human epidermoid carcinoma cells (A431) expressing either GFP-tagged F-actin (green) or m-Ruby-tagged E-cadherin (magenta) and migrating collectively to seal a gap in the tissue.